Studies on WF-3161, a new antitumor antibiotic.

نویسندگان

  • K Umehara
  • K Nakahara
  • S Kiyoto
  • M Iwami
  • M Okamoto
  • H Tanaka
  • M Kohsaka
  • H Aoki
  • H Imanaka
چکیده

WF-3161 is an antitumor antibiotic produced by a strain of fungus, Petriella guttulata. The antibiotic was purified by solvent extraction and a combination of silica gel and reverse phase column chromatography. The chemical structure of the antibiotic (C31H44N4O6, mp 181-183 degrees C) was found to be a cyclic tetrapeptide consisting of phenylalanine, leucine, pipecolinic acid and 2-amino-8-oxo-9,10-epoxydecanoic acid. WF-3161 inhibited the growth of Trichophyton asteroides. It prolonged survival period of mice bearing leukemia P-388 with a high therapeutic index.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 36 5  شماره 

صفحات  -

تاریخ انتشار 1983